Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression
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چکیده
and resilient mice. (a) Schematic detailing time-course of chronic social defeat, social interaction testing and tissue collection. (b) To identify susceptible and resilient mice, a social interaction ratio (time in interaction zone with social target/time with target absent) was calculated for each mouse based on (c) behavior in the social interaction test 24 hr after CSDS (susceptible ratio <1; resilient ratio >1).
منابع مشابه
Corrigendum: Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression
Enhanced glutamatergic transmission in the nucleus accumbens (NAc), a region critical for reward and motivation, has been implicated in the pathophysiology of depression; however, the afferent source of this increased glutamate tone is not known. The NAc receives glutamatergic inputs from the medial prefrontal cortex (mPFC), ventral hippocampus (vHIP) and basolateral amygdala (AMY). Here, we de...
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